[PLAGUES] COVID-19, H5N1, probably demodex eventually

[UAE Bird Expert]

https://linktr.ee/patrickthebiosteamist ... 2e67ae9f6d

[PanAccIndex]

Finally, the thread for me!

[crystalchandeliers]

Amazon now stocks a 3-in-1 rapid test that detects flu A (incl bird flu h5n1), flu B, and covid-19.

Currently it costs $40 for 4 tests, which works out to $10 per test. This is a good price IMO. Cheapest I’d seen yet was at PharmaLynk for a CorDx test for $18-21 per test.

https://www.amazon.com/iHealth-COVID-19 ... 0D3T1X1FS/

Screen Shot 2024-07-26 at 18.37.15.png (1.43 MiB) Viewed 12046 times

[UAE Bird Expert]

After decreasing sharply during March and April 2020 while most states had stay-at-home orders in effect, monthly traffic fatalities returned to typical levels in May 2020. Then, in June, traffic fatalities surged to levels significantly greater than would have been expected without the pandemic and remained elevated throughout the remainder of 2020 as well as the entirety of 2021 and 2022. From May 2020 through December 2022, 114,528 people were killed in traffic crashes on U.S. roads, an estimated 16,771 (17%) more than would have been expected if the pandemic had not occurred and pre-pandemic trends continued (see Figure).

[UAE Bird Expert]

Study reveals new H5N1 variants evade human antibodies more effectively

In a new study led by UNC Charlotte researchers from the Center for Computational Intelligence to Predict Health and Environmental Risks (CIPHER) and the North Carolina Research Campus at Kannapolis, University scholars have found evidence that the latest variants of H5N1 influenza -; commonly known as avian or bird flu -; are better at evading antibodies, including those of humans, than previous iterations of the virus. The study is currently published as a preprint on the online bioRxiv preprint server for biology research and is awaiting peer-review.

[UAE Bird Expert]

Nice nice nice

[PanAccIndex]

Here's the latest edition of "What COVID-19 Does to the Body," which compiles over 100+ recent studies on SARS-CoV-2 harms and prevention - sorted by organ and topic: https://www.panaccindex.info/p/what-cov ... body-fifth

After five editions, this is an overwhelming amount of research (500+) that details the importance of preventing COVID-19 infections.

[UAE Bird Expert]

Favorable Antiviral Effect of Metformin on Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load in a Randomized, Placebo-Controlled Clinical Trial of Coronavirus Disease 2019

Background

Metformin has antiviral activity against RNA viruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The mechanism appears to be suppression of protein translation via targeting the host mechanistic target of rapamycin pathway. In the COVID-OUT randomized trial for outpatient coronavirus disease 2019 (COVID-19), metformin reduced the odds of hospitalizations/death through 28 days by 58%, of emergency department visits/hospitalizations/death through 14 days by 42%, and of long COVID through 10 months by 42%.
Methods

COVID-OUT was a 2 × 3 randomized, placebo-controlled, double-blind trial that assessed metformin, fluvoxamine, and ivermectin; 999 participants self-collected anterior nasal swabs on day 1 (n = 945), day 5 (n = 871), and day 10 (n = 775). Viral load was quantified using reverse-transcription quantitative polymerase chain reaction.
Results

The mean SARS-CoV-2 viral load was reduced 3.6-fold with metformin relative to placebo (−0.56 log10 copies/mL; 95% confidence interval [CI], −1.05 to −.06; P = .027). Those who received metformin were less likely to have a detectable viral load than placebo at day 5 or day 10 (odds ratio [OR], 0.72; 95% CI, .55 to .94). Viral rebound, defined as a higher viral load at day 10 than day 5, was less frequent with metformin (3.28%) than placebo (5.95%; OR, 0.68; 95% CI, .36 to 1.29). The metformin effect was consistent across subgroups and increased over time. Neither ivermectin nor fluvoxamine showed effect over placebo.

Conclusions

In this randomized, placebo-controlled trial of outpatient treatment of SARS-CoV-2, metformin significantly reduced SARS-CoV-2 viral load, which may explain the clinical benefits in this trial. Metformin is pleiotropic with other actions that are relevant to COVID-19 pathophysiology.

[duckenheimer]

Increase in Human Parvovirus B19 Activity in the United States
https://emergency.cdc.gov/han/2024/han00514.asp

Advisory to notify healthcare providers, public health authorities, and the public about current increases in human parvovirus B19 activity in the United States.

Data include increased test positivity for parvovirus B19 in clinical specimens and pooled plasma from a large commercial laboratory, and reports of clusters of parvovirus B19-associated complications among pregnant people and people with sickle cell disease.

The proportion of people with IgM antibodies, an indicator of recent infection, increased among all ages from <3% during 2022–2024 to 10% in June 2024; the greatest increase was observed among children aged 5–9 years, from 15% during 2022–2024 to 40% in June 2024.

Among plasma donors, the prevalence of pooled samples with parvovirus B19 DNA >104 IU/mL increased from 1.5% in December 2023 to 19.9% in June 2024.

What an interesting mystery. Hey look, I found a clue!

Parvovirus B19 is highly transmissible in respiratory droplets

Is the country that's been "quietly preparing" for a bird flu pandemic in the room with us right now?

[Diplotomodon]

Alright so what's the deal with Novavax

Apparently it's doing well against the covid variant du jour but the FDA isn't approving it yet?