[PLAGUES] COVID-19, H5N1, probably demodex eventually

[UAE Bird Expert]

LA Times posted:
‘Playing COVID roulette’: Some infected by FLiRT variants report their most unpleasant symptoms yet

There are no signs at this point that the latest coronavirus variants are producing more severe illness, either nationally or in California.

But some doctors say this latest COVID rise challenges a long-held myth: While new COVID infections are often mild compared to a first brush with the disease, they still can cause severe illness. Even if someone doesn’t need to visit the emergency room or be hospitalized, people sometimes describe agonizing symptoms.

“The dogma is that every time you get COVID, it’s milder. But I think we need to keep our minds open to the possibility that some people have worse symptoms,” said Dr. Peter Chin-Hong, a UC San Francisco infectious diseases expert.

Each time you get COVID, he said, is “kind of like playing COVID roulette.”

This underscores the need for caution during summer travel and activities, even though the overall risk remains relatively mild.

Since everyone’s experience with COVID is different and influenced by a number of factors, it’s difficult to quantify how many are experiencing more acute symptoms now compared with previous infections. But anecdotally, including on social media sites, people are expressing shock at how sick they’ve become from the latest subvariants, which have been collectively nicknamed FLiRT.

“I’ve had COVID a few times but this is the worst I’ve had it,” wrote one person on Reddit. The person reported recurring fever, being so congested they couldn’t breathe out of their nose, “terrible sinus pressure and headache ... and I can’t stand up for too long without feeling like I’m about to pass out.”

“Previously COVID just felt like the common cold, but this strain is [wreaking] havoc,” the person wrote. “I don’t like to complain like this, but I’m shocked at how much it’s taking me out.”

Another person wrote that their “throat feels like razor blades” and that they feel like they’re “in living misery.”

“I have so much phlegm, but it hurts so bad to cough because my throat is on literal fire!!” the person wrote. “This is my 4th time having Covid and I swear I feel like this is the worst it’s ever been!!”

Others who eluded COVID for more than four years got infected this summer.

One person fell ill and tested positive for the first time after hosting a Father’s Day gathering for 12 people. The person described “uncontrollable body-shaking chills so bad I couldn’t feel most of my fingertips.”

A 42-year-old nurse, who has had COVID four times, said their latest illness has been “intense with fevers, cough, head pressure and pain. It’s attacking my throat and ability to swallow.”

Others, though, have said each subsequent COVID illness has been easier to recover from. And one first-time infected person wrote that they had “super mild symptoms [that] just feels like a seasonal allergy” flare-up.

Some studies back up the idea that subsequent COVID infections pose additional risks. A 2022 report in the journal Nature Medicine, focused on veterans, found that, “Compared to noninfected [people], cumulative risks and burdens of repeat infection increased according to the number of infections,” heightening the risk of medical problems, hospitalization and death.

And while the prevalence of long COVID appears to be declining, doctors note there is risk of developing the syndrome with each infection. A report published by the U.S. Centers for Disease Control and Prevention last summer said the prevalence of long COVID among U.S. adults was 7.5% in early June 2022, but had decreased as of mid-June 2023 to 6% — still a notable share of the population.

There are a number of potential reasons why a subsequent COVID illness might feel worse than the first. Say a person who was vaccinated and last boosted in 2021 got infected in 2022 and then again in 2024. The relatively long gap of not being exposed to infection, or a booster, “maybe led to [their body] not having as much immune memory. And the variants have changed so much anyway, it’s like getting exposed to something relatively different from what virus the immune system had seen earlier,” Chin-Hong said.

Without staying up-to-date on COVID vaccinations, which “remind the immune system of what the more current variants look like,” a recent infection may cause the body to act relatively surprised to the FLiRT subvariants that are now dominant nationwide.

“It’s evolved so much, and the body is, like, ‘O-M-G, what is this thing that I’m seeing?’ ” Chin-Hong said.

The logic is much the same for annual flu shots, which are formulated each year in hopes of priming the immune system against the dominant circulating versions of that virus.

Chin-Hong said that even healthcare workers need to be reminded of proper COVID infection control protocols, like the importance of testing when you feel sick, and reporting your illness to your employer.

“It’s like everybody seems to be thinking COVID is just like normal now,” Chin-Hong said. But taking sensible measures — like coworkers deciding to not go into work when sick, and testing themselves when symptomatic — can make a world of difference in keeping COVID limited to a smaller number of people.

And with COVID rising, it’s also a reminder that it’s sensible to keep a mask in your pocket to don if you happen to be near an ill person, Chin-Hong said.

[UAE Bird Expert]

MUST READ!!!!!

https://www.cell.com/iscience/fulltext/ ... all%3Dtrue

[UAE Bird Expert]

Yeah I feel like I'm going crazy

[UAE Bird Expert]

[nomadwarp]

[Diplotomodon]

Bird flu? I sure hope it did

[UAE Bird Expert]

[UAE Bird Expert]

This is my exact situation

[UAE Bird Expert]

Something awful plague thread

[UAE Bird Expert]

Tracking cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection"
https://www.nature.com/articles/s43587-024-00667-3 posted:
Abstract

Emerging evidence suggests that neurological and other post-acute sequelae of COVID-19 can persist beyond or develop following SARS-CoV-2 infection. However, the long-term trajectories of cognitive change after a COVID-19 infection remain unclear. Here we investigated cognitive changes over a period of 2.5 years among 1,245 individuals aged 60 years or older who survived infection with the original SARS-CoV-2 strain in Wuhan, China, and 358 uninfected spouses. We show that the overall incidence of cognitive impairment among older COVID-19 survivors was 19.1% at 2.5 years after infection and hospitalization, evaluated using the Telephone Interview for Cognitive Status-40. Cognitive decline primarily manifested in individuals with severe COVID-19 during the initial year of infection, after which the rate of decline decelerated. Severe COVID-19, cognitive impairment at 6 months and hypertension were associated with long-term cognitive decline. These findings reveal the long-term cognitive trajectory of the disease and underscore the importance of post-infection cognitive care for COVID-19 survivors